Autoimmune polyendocrine syndrome type 1 (APS-1) is a life-threatening, autosomal recessive syndrome caused by autoimmune ...

Approved on-demand treatments for hereditary angioedema attacks need to be administered parenterally, a route of ...

Hereditary angioedema is a rare disorder characterized by recurrent episodes of mucosal swelling. The disease is usually ...

Many of the challenges we address here were evident to the pioneers of medical decision analysis of the 1950s 7 and to scholars in subsequent decades 8-11 who conducted careful and creative ...

Angiopoietin-like 3 (ANGPTL3) inhibits lipoprotein and endothelial lipases and hepatic uptake of triglyceride-rich lipoprotein remnants. ANGPTL3 loss-of-function carriers have lower levels of ...

On September 11, 2023, the updated Moderna and Pfizer–BioNTech mRNA vaccines (i.e., 2023–2024 formulas) against coronavirus disease 2019 (Covid-19) containing the severe acute respiratory ...

Experiments 1 through 3 were performed with the PCR thermocycler lid closed and at a default setting of 105°C. Experiments 4 and 5 were performed with the PCR thermocycler lid open and a metal ...

We carried out a 48-week, phase 2b, double-blind, randomized, placebo-controlled trial evaluating the safety and efficacy of plozasiran, a hepatocyte-targeted APOC3 small interfering RNA, in ...

The increasingly widespread availability of genomic sequencing has enabled the identification of persons and families with uniquely favorable traits, including a very low incidence of clinical events.

Patients with type 2 diabetes and chronic kidney disease are at high risk for kidney failure, cardiovascular events, and death. Whether treatment with semaglutide would mitigate these risks is ...

Antibody-mediated rejection is a leading cause of kidney-transplant failure. The targeting of CD38 to inhibit graft injury caused by alloantibodies and natural killer (NK) cells may be a ...

A 70-year-old woman with diabetes presented with epigastric pain and vomiting. ECG showed normal sinus rhythm with pathologic Q waves and T-wave inversions in the anterior leads. Ventriculography ...